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Hydroxyproline is mostly used as a diagnostic marker of bone turnover and liver fibrosis. Therapeutically, hydroxyproline is being studied as an an experimental medicine but is approved in France as a combination topical gel product called Cicactive for small, superficial wounds.
The daily turnover of collagen in humans is estimated to be 2–3 g/day,4 leading to the metabolism of 240–420 mg of hydroxyproline and the formation of 140–240 mg of glyoxylate
The individual amino acid solutions show evidence of oscillatory oligomerization. In the binary solution, the behavior is controlled by the dynamics of L-Pro oligomerization. A simple model involving oligomerization, formation of catalytic oligomer aggregates and cross-catalysis provides qualitative insight into the process.
L HYDROXYPROLINE FOR BIOCHEMISTRY
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