Product code RXSOL-60-6605-251Category Lab Chemical

Price and availability on request. Send us the quantity and delivery location in Oman.

Product description

Synthesis of phthalimides. An efficient and simple method enables the N-alkylation of aromatic cyclic imides using cesium carbonate as the base in anhydrous N,N-dimethylformamide at low 
temperatures (20-70˚C). The method is compatible with base labile functional groups.

Applications

The Synthesis is used to get primary amines from primary alkyl halides and is named after the German scientist Siegmund Gabriel. The reaction has been generalized for applications in the alkylation of sulfonamides and imides & their deprotection in order to obtain amines.

Dosage

The required doses corresponding to 300mg/kg, 100mg/kg and 30mg/kg body.

Also known as

PHTHALIMIDE FOR SYNTHESIS

Notes

Paecilocin A, a phthalide derivative isolated from the jellyfish-derived fungus Paecilomyces variotii, activates PPAR-γ (Peroxisome proliferator-activated receptor gamma) in rat liver Ac2F cells. Based on a SAR (Structure-activity relationships) study and in silico analysis of paecilocin A-mimetic derivatives, additional N-substituted phthalimide derivatives were synthesized and evaluated for PPAR-γ agonistic activity in both murine liver Ac2F cells and in human liver HepG2 cells by luciferase assay, and for adipogenic activity in 3T3-L1 cells. Docking simulation indicated PD6 was likely to bind most strongly to the ligand binding domain of PPAR-γ by establishing crucial H-bonds with key amino acid residues.

Where we supply

Oman. Stocked at our warehouse in Barka, South Al Batinah, and supplied to Muscat, Ruwi, Mutrah, Seeb, Rusayl, Barka, Sohar, Shinas, Saham, Buraimi, Nizwa, Ibri, Sur, Salalah, Duqm, Khasab and every other governorate.

Ports and free zones. Port Sultan Qaboos (Mutrah), Mina Al Fahal, Sohar Port and Freezone, Port of Salalah and Salalah Free Zone, Port of Duqm and the Duqm Special Economic Zone, Port of Sur, Khasab Port and Al Mazunah Free Zone.

Industrial areas. Rusayl, Sohar, Barka (Sanaya), Raysut (Salalah), Nizwa, Sur, Buraimi and Duqm industrial estates, Knowledge Oasis Muscat, and oil and gas sites across Oman.

Beyond Oman. We have branches in the UAE (including Fujairah) and in India (Kandla, Kolkata, Visakhapatnam, Chennai and Mumbai), and we also supply to South Africa.