Product code RXSOL-60-6604-395Category Lab Chemical

Price and availability on request. Send us the quantity and delivery location in Oman.

Product description

Synthesis of sup 14/C-cysteamine and cystamine. Bulgaria. The cysteamine hydrochloride compound was obtained by dissolving 100 mg of the cysteamine salicylate in 5 ml of water, acidifying with concentrated hydrochloric acid to a pH of 1 to 2, and extracting with 5 ml of ether five times. Yield is 90 percent.

Applications

Cysteamine is a cystine depleting agent used to treat the effects of cystinosis. Cystinosis is a rare disease caused by mutations in the CTNS gene that encodes for cystinosin, a protein responsible for transporting cystine out of the cell lysosome.

Dosage

110 lbs or more:
-Initial dose: 0.3 to 0.5 g/day orally divided in 4 doses. Increase dose gradually over 4 to 6 weeks if the WBC cystine level remains above 2 nmol half-cystine/mg protein.
-Maintenance dose: 2 g/day orally divided in 4 doses
 
Delayed-release capsule:
-Initial dose: 0.2 to 0.3 g/m2/day orally divided in 2 doses, every 12 hours. Increase dose gradually over 4 to 6 weeks if the WBC cystine level remains above 1 nmol half-cystine/mg protein.
-Maintenance dose: 1.3 g/m2/day orally divided in 2 doses, every 12 hours
Maximum dose: 1.95 g/m2/day
-Maximum dose: 1.95 g/m2/day110 lbs or more:
-Initial dose: 0.3 to 0.5 g/day orally divided in 4 doses. Increase dose gradually over 4 to 6 weeks if the WBC cystine level remains above 2 nmol half-cystine/mg protein.
-Maintenance dose: 2 g/day orally divided in 4 doses
 
Delayed-release capsule:
-Initial dose: 0.2 to 0.3 g/m2/day orally divided in 2 doses, every 12 hours. Increase dose gradually over 4 to 6 weeks if the WBC cystine level remains above 1 nmol half-cystine/mg protein.
-Maintenance dose: 1.3 g/m2/day orally divided in 2 doses, every 12 hours
-Maximum dose: 1.95 g/m2/day

Also known as

CYSTEAMINE HYDROCHLORIDE for synthesis

Notes

Cysteamine, as a part of CoA plays a crucial role in metabolism by facilitating thioester formation. However, as a free entity, cysteamine is largely absent from metabolism. By contrast, supraphysiological amounts of this simple aminothiol have profound and selective effects of physiology and certain diseases. 

Where we supply

Oman. Stocked at our warehouse in Barka, South Al Batinah, and supplied to Muscat, Ruwi, Mutrah, Seeb, Rusayl, Barka, Sohar, Shinas, Saham, Buraimi, Nizwa, Ibri, Sur, Salalah, Duqm, Khasab and every other governorate.

Ports and free zones. Port Sultan Qaboos (Mutrah), Mina Al Fahal, Sohar Port and Freezone, Port of Salalah and Salalah Free Zone, Port of Duqm and the Duqm Special Economic Zone, Port of Sur, Khasab Port and Al Mazunah Free Zone.

Industrial areas. Rusayl, Sohar, Barka (Sanaya), Raysut (Salalah), Nizwa, Sur, Buraimi and Duqm industrial estates, Knowledge Oasis Muscat, and oil and gas sites across Oman.

Beyond Oman. We have branches in the UAE (including Fujairah) and in India (Kandla, Kolkata, Visakhapatnam, Chennai and Mumbai), and we also supply to South Africa.